Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report

Br J Neurosurg. 2013 Apr;27(2):259-61. doi: 10.3109/02688697.2012.741740. Epub 2012 Nov 19.

Abstract

Radiation-induced gliomas are uncommon and therapeutic options are limited due to prior exposure to radiotherapy. Meanwhile, the chemotherapeutic response of anaplastic ependymoma, another rare entity in adults, is often disappointing. We report on the first recorded case of radiation-induced anaplastic ependymoma, in which an excellent clinical response to temozolomide was demonstrated.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Astrocytoma / radiotherapy
  • Astrocytoma / surgery
  • Cerebellar Neoplasms / radiotherapy
  • Cerebellar Neoplasms / surgery
  • Dacarbazine / analogs & derivatives*
  • Dacarbazine / therapeutic use
  • Ependymoma / drug therapy*
  • Female
  • Humans
  • Neoplasms, Radiation-Induced / drug therapy*
  • Neoplasms, Second Primary / drug therapy*
  • Temozolomide

Substances

  • Antineoplastic Agents, Alkylating
  • Dacarbazine
  • Temozolomide