Evaluation of cell function upon nanovector internalization

Jonathan O Martinez; Alessandro Parodi; Xuewu Liu; Mikhail G Kolonin; Mauro Ferrari; Ennio Tasciotti

doi:10.1002/smll.201202001

Evaluation of cell function upon nanovector internalization

Small. 2013 May 27;9(9-10):1696-702. doi: 10.1002/smll.201202001. Epub 2012 Nov 20.

Authors

Jonathan O Martinez¹, Alessandro Parodi, Xuewu Liu, Mikhail G Kolonin, Mauro Ferrari, Ennio Tasciotti

Affiliation

¹ Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.

Abstract

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Survival*
Cells, Cultured
Endocytosis*
Humans
Nanoparticles*

Abstract

Publication types

MeSH terms

Grants and funding