Abstract
Arthrofactin, a bioactive cyclic lipopeptide from Pseudomonas sp. MIS38, was reinvestigated for its structural and stereochemical features due to discrepancies between the genetics-based sequence prediction and the currently suggested structure. The structure of arthrofactin and its derivatives was reassigned on the basis of chiral HPLC analysis and extensive NMR and MS experiments. Furthermore, derivatives of arthrofactin were discovered.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Computational Biology / methods*
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Lipopeptides / chemistry*
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Lipopeptides / genetics
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Lipopeptides / metabolism
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Molecular Sequence Data
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Multigene Family / genetics
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / genetics
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Peptides, Cyclic / metabolism
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Phylogeny
Substances
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Bacterial Proteins
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Lipopeptides
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Peptides, Cyclic
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arthrofactin