Abstract
Core binding factor beta (CBFβ), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFβ. We also revealed that different lengths and regions are required for CBFβ to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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APOBEC-3G Deaminase
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Core Binding Factor Alpha 2 Subunit / metabolism*
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Core Binding Factor beta Subunit / genetics
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Core Binding Factor beta Subunit / metabolism*
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Cytidine Deaminase / metabolism*
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HIV-1 / pathogenicity
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HIV-1 / physiology*
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Protein Interaction Domains and Motifs
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Transcription, Genetic*
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vif Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor beta Subunit
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RUNX1 protein, human
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vif Gene Products, Human Immunodeficiency Virus
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vif protein, Human immunodeficiency virus 1
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APOBEC-3G Deaminase
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APOBEC3G protein, human
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Cytidine Deaminase