Abstract
Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal, our case showed that intensive peritoneal dialysis regimen leads to the recovery of neurotoxicity after 3 days.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / therapy*
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Acyclovir / adverse effects
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Acyclovir / analogs & derivatives*
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Acyclovir / therapeutic use
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Aged
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Antiviral Agents / adverse effects
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Antiviral Agents / therapeutic use
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Female
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Follow-Up Studies
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Herpes Zoster / diagnosis
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Herpes Zoster / drug therapy*
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Humans
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Kidney Failure, Chronic / diagnosis
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Kidney Failure, Chronic / therapy
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Kidney Function Tests
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Peritoneal Dialysis, Continuous Ambulatory / methods*
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Risk Assessment
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Treatment Outcome
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Valacyclovir
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Valine / adverse effects
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Valine / analogs & derivatives*
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Valine / therapeutic use
Substances
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Antiviral Agents
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Valine
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Valacyclovir
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Acyclovir