Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion

Adv Healthc Mater. 2013 Jun;2(6):790-4. doi: 10.1002/adhm.201200320. Epub 2012 Nov 26.

Abstract

Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology*
  • Adenocarcinoma / physiopathology*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / physiopathology*
  • Cell Line, Tumor
  • Cell Separation / instrumentation
  • Equipment Design
  • Equipment Failure Analysis
  • Extracellular Matrix / diagnostic imaging*
  • Extracellular Matrix / metabolism*
  • Humans
  • Microfluidic Analytical Techniques / instrumentation*
  • Neoplasm Invasiveness / pathology
  • Neoplasm Invasiveness / physiopathology
  • Ultrasonography