Magnetic nanocomposite sol-gel systems for remote controlled drug release

Ashley M Hawkins; Chelsie E Bottom; Zhi Liang; David A Puleo; J Zach Hilt

doi:10.1002/adhm.201100013

Magnetic nanocomposite sol-gel systems for remote controlled drug release

Adv Healthc Mater. 2012 Jan 11;1(1):96-100. doi: 10.1002/adhm.201100013. Epub 2011 Dec 9.

Authors

Ashley M Hawkins¹, Chelsie E Bottom, Zhi Liang, David A Puleo, J Zach Hilt

Affiliation

¹ Department of Chemical and Materials Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, KY 40506-0046, USA.

PMID: 23184692
DOI: 10.1002/adhm.201100013

Abstract

The remote heating of iron oxide nanoparticles in an alternating magnetic field is used to drive a thermoresponsive sol-gel block copolymer, Pluronic® F-127, through the upper phase transition temperature. This phase change triggers an accelerated release rate of a model drug. Actuation and return to baseline levels are demonstrated for multiple AMF doses.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Delayed-Action Preparations / chemistry*
Delayed-Action Preparations / radiation effects*
Ferric Compounds / chemistry*
Ferric Compounds / radiation effects
Materials Testing
Nanoparticles / chemistry*
Nanoparticles / radiation effects
Nanoparticles / ultrastructure
Phase Transition
Poloxamer / chemistry*

Substances

Delayed-Action Preparations
Ferric Compounds
Poloxamer
ferric oxide