Biomineralization-based virus shell-engineering: towards neutralization escape and tropism expansion

Adv Healthc Mater. 2012 Jul;1(4):443-9. doi: 10.1002/adhm.201200034. Epub 2012 Mar 28.

Abstract

Biomineralization-based virus shell-engineering (BVSE) is a potential surface modification strategy to afford a biocompatible and biodegradable calcium phosphate (CaPi) shell onto single virus, allowing development of Trojan virus with enhanced infection, expanded tropism and neutralization escape, which open up the multiple applications of virus in biomedicines and materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae / chemistry*
  • Adenoviridae / genetics*
  • Adenoviridae / ultrastructure
  • Biocompatible Materials / chemistry
  • Calcium Phosphates / chemistry*
  • Capsid / chemistry*
  • Capsid / physiology*
  • Capsid / ultrastructure
  • Genetic Engineering / methods*
  • Minerals / chemistry
  • Viral Tropism / physiology

Substances

  • Biocompatible Materials
  • Calcium Phosphates
  • Minerals
  • calcium phosphate