Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles

Zi Gu; Barbara E Rolfe; Zhi Ping Xu; Julie H Campbell; G Q Max Lu; Anita C Thomas

doi:10.1002/adhm.201200069

Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles

Adv Healthc Mater. 2012 Sep;1(5):669-73. doi: 10.1002/adhm.201200069. Epub 2012 Jul 12.

Authors

Zi Gu¹, Barbara E Rolfe, Zhi Ping Xu, Julie H Campbell, G Q Max Lu, Anita C Thomas

Affiliation

¹ ARC Centre of Excellence for Functional Nanomaterials, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.

PMID: 23184804
DOI: 10.1002/adhm.201200069

Abstract

Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / administration & dosage*
Carotid Artery Injuries / drug therapy*
Carotid Artery Injuries / pathology*
Hydroxides / chemistry*
Male
Materials Testing
Nanocapsules / chemistry
Nanocapsules / therapeutic use*
Rats
Rats, Wistar
Treatment Outcome

Substances

Antibodies, Monoclonal
Hydroxides
Nanocapsules