[Synthesis of p(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-galactopyranosyl) diphosphate and p(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-glucopyranosyl) diphosphate; assay of their acceptor properties for mannosyl residue in the enzmic reaction catalyzed by mannosyltransferase from Salmonella newport]

Bioorg Khim. 2012 Jul-Aug;38(4):472-6. doi: 10.1134/s1068162012040140.
[Article in Russian]

Abstract

P(1)-(Phenoxyundecyl)-P(2)-(alpha-D-galactopyranosyl) diphosphate as well as P(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-glucopyranosyl) diphosphate are newly synthesized and their ability to serve as substrate-acceptor of mannosyl residue in enzymic reaction catalyzed by mannosyltransferase from Salmonella newport membrane preparation is investigated. The possibility ofgalactosyl-containing derivative to serve as mannosyl acceptor from GDP-Man is established whereas glucosyl-containing compound is inactive in this process.

Publication types

  • English Abstract

MeSH terms

  • Glycosides / chemical synthesis*
  • Glycosides / chemistry
  • Mannosyltransferases / chemistry
  • Organophosphates / chemical synthesis*
  • Organophosphates / chemistry
  • Salmonella / enzymology
  • Substrate Specificity
  • Sugar Phosphates / chemical synthesis*
  • Sugar Phosphates / chemistry

Substances

  • Glycosides
  • Organophosphates
  • P(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-galactopyranosyl) diphosphate
  • P(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-glucopyranosyl) diphosphate
  • Sugar Phosphates
  • Mannosyltransferases