Abstract
The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in an efficient manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Cyclization
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Hydrocarbons, Iodinated / chemistry*
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Ketones / chemistry*
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Molecular Structure
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Quaternary Ammonium Compounds / chemistry*
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Stereoisomerism
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tert-Butylhydroperoxide / chemistry*
Substances
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Alkynes
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Hydrocarbons, Iodinated
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Ketones
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Quaternary Ammonium Compounds
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tert-Butylhydroperoxide
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tetrabutylammonium