Ultrasound vibrometry can measure the propagation velocity of shear waves in soft tissue noninvasively, and the shear moduli of tissue can be estimated inversely from the velocities at multiple frequencies. It is possible to choose the appropriate model for tissue characterization from mathematical methods and analysis of model behaviors. The three classic models, Voigt, Maxwell, and Zener, were applied to fit the velocity measurements and estimate shear moduli of porcine livers with different thermal damage levels and different storage times. The Zener model always provided the best estimation of the moduli with the minimum errors in our experiments. Unlike the Voigt and Maxwell models, the moduli of the Zener model cannot be used to indicate damage levels in porcine livers directly, but the creep and relaxation behaviors of the Zener model are effective.