We report on a patient who was treated with several antiarrhythmic drugs as well as different ablation strategies. Nevertheless, symptomatic atrial fibrillation always recurred until an off-label use with ranolazine was started. We could demonstrate potent effects of ranolazine on atrial fibrillation in a "wash-in wash-out" situation. Although promising controlled studies are needed to investigate a potential role of ranolazine for the treatment of atrial fibrillation.
Keywords: Antiarrhythmic drugs; Atrial fibrillation; Pulmonary vein isolation; Ranolazine.
© 2012 John Wiley & Sons Ltd.