⁹⁹mTc-N4amG: synthesis biodistribution and imaging in breast tumor-bearing rodents

Appl Radiat Isot. 2013 Feb:72:105-13. doi: 10.1016/j.apradiso.2012.07.018. Epub 2012 Oct 11.

Abstract

(99m)Tc-N4-guanine ((99m)Tc-N4amG) was synthesized and evaluated in this study. Cellular uptake and cellular fraction studies were performed to evaluate the cell penetrating ability. Biodistribution and planar imaging were conducted in breast tumor-bearing rats. Up to 17%ID uptake was observed in cellular uptake study with 40% of (99m)Tc-N4amG was accumulated in the nucleus. Biodistribution and scintigraphic imaging studies showed increased tumor/muscle count density ratios as a function of time. Our results demonstrate the feasibility of using (99m)Tc-N4amG in tumor specific imaging.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Female
  • Magnetic Resonance Spectroscopy
  • Mammary Neoplasms, Experimental / metabolism*
  • Organotechnetium Compounds / chemical synthesis*
  • Organotechnetium Compounds / pharmacokinetics*
  • Radiation Dosage
  • Rats
  • Rats, Inbred F344
  • Tissue Distribution

Substances

  • Organotechnetium Compounds