The broad spectrum of CNS listeriosis is expanded by the observation of an intracerebral infarction associated with meningoencephalitis. Sequential CCT scans in a 66-year-old immuno-compromised woman led to the clinical diagnosis of brain abscess. Autopsy revealed an infected intracerebral infarction most probably due to temporal occlusion of the middle cerebral artery by septic microemboli or septic endothelial damage.