Abstract
Vaccinia-related kinase 1 (VRK1) is one of the mitotic kinases which play key roles in cell cycle control and chromatin modifications. To understand the biological role of the kinase and gain insights into its catalytic mechanism, we performed NMR assignments of catalytically active form of VRK1 with 361 amino acids residues. Here, we present the backbone NMR resonance assignments of the kinase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon Isotopes
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Humans
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Hydrogen
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Intracellular Signaling Peptides and Proteins / chemistry*
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Nitrogen Isotopes
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Nuclear Magnetic Resonance, Biomolecular*
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Protein Serine-Threonine Kinases / chemistry*
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Protein Structure, Secondary
Substances
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Carbon Isotopes
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Intracellular Signaling Peptides and Proteins
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Nitrogen Isotopes
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Hydrogen
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Protein Serine-Threonine Kinases
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VRK1 protein, human