Formal synthesis of cephalotaxine

J Org Chem. 2013 Jan 18;78(2):786-90. doi: 10.1021/jo302608a. Epub 2012 Dec 17.

Abstract

A formal synthesis of cephalotaxine, the parent member of the Cephalotaxus alkaloids, was achieved. It features a practical four-step assembly of the benzazepine-bearing pentacyclic ring system through two alkylation reactions, acidic hydrolysis, and aldolization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Benzazepines / chemistry*
  • Harringtonines / chemical synthesis*
  • Homoharringtonine
  • Hydrolysis
  • Molecular Structure

Substances

  • Benzazepines
  • Harringtonines
  • Homoharringtonine