Dual amine and palladium catalysis in diastereo- and enantioselective allene carbocyclization reactions

Org Lett. 2012 Dec 21;14(24):6350-3. doi: 10.1021/ol303128s. Epub 2012 Dec 6.

Abstract

A pyrrolidine and Pd catalyzed diastereoselective carbocyclization of aldehyde and ketone-linked allenes has been developed. The cooperative organo/metal-catalyzed cyclization reaction, which presumably proceeds via an enamine intermediate, is efficient and broad in scope. Also, it has been extended to a catalytic asymmetric variant using diarylprolinol-based organocatalysts to afford substituted cyclopentane and pyrrolidine reaction products in up to 82% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Cyclization
  • Cyclopentanes / chemical synthesis*
  • Cyclopentanes / chemistry
  • Ketones / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Aldehydes
  • Amines
  • Cyclopentanes
  • Ketones
  • Palladium