Abstract
This study revealed that CWR22Rv-1 cells overexpressing δ-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, δ-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1α and vascular endothelial growth factor (VEGF) expression. Furthermore, δ-catenin overexpression was found to enhance nuclear distribution of both β-catenin and HIF-1α in hypoxic condition, which is diminished by knockdown of δ-catenin. Our current study adds novel evidence regarding contribution of δ-catenin to the progression of prostate cancer.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Catenins / antagonists & inhibitors
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Catenins / genetics
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Catenins / metabolism*
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Cell Line, Tumor
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Cell Nucleus / metabolism
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Chick Embryo
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Delta Catenin
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Gene Expression
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Gene Knockdown Techniques
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
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Male
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Neovascularization, Pathologic*
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Prostatic Neoplasms / blood supply*
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / metabolism*
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Signal Transduction
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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Catenins
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Delta Catenin