[Role of antithrombin iii in cardiac surgery]

Rev Esp Anestesiol Reanim. 2013 Nov;60(9):519-27. doi: 10.1016/j.redar.2012.09.025. Epub 2012 Dec 8.
[Article in Spanish]

Abstract

Coagulation of blood is of multidisciplinary interest. Cardiac surgery produces major changes in the delicate balance between pro-and anti-coagulant serum factors. The role of antithrombin iii has been analysed after finding evidence that associated decreased levels of protein activity to postoperative morbidity and mortality. Supplementing exogenous antithrombin is considered with the aim of optimising outcomes. Its intrinsic anticoagulant and anti-inflammatory properties have stimulated a growing interest, and suggests new lines of research.

Keywords: Antithrombin; Antitrombina; Cardiac surgery; Cirugía cardiaca; Coagulación; Coagulation; Inflamación; Inflammation; Morbidity; Morbilidad.

Publication types

  • English Abstract

MeSH terms

  • Antithrombin III / analysis
  • Antithrombin III / physiology*
  • Antithrombin III / therapeutic use
  • Antithrombin III Deficiency / drug therapy
  • Antithrombin III Deficiency / etiology
  • Antithrombin III Deficiency / mortality
  • Cardiac Surgical Procedures*
  • Extracorporeal Circulation / adverse effects
  • Humans
  • Systemic Inflammatory Response Syndrome / etiology

Substances

  • Antithrombin III