Abstract
Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4(+) and CD8(+) T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Retroviral Agents / administration & dosage*
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Anti-Retroviral Agents / adverse effects
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Antiretroviral Therapy, Highly Active / adverse effects
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Antiretroviral Therapy, Highly Active / methods*
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CD4-Positive T-Lymphocytes / virology
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CD8-Positive T-Lymphocytes / virology
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Coinfection / drug therapy
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HIV Infections / complications
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HIV Infections / drug therapy*
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HTLV-I Infections / virology*
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Human T-lymphotropic virus 1 / drug effects*
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Human T-lymphotropic virus 1 / isolation & purification
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Human T-lymphotropic virus 1 / pathogenicity*
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Humans
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Proviruses / drug effects
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Proviruses / isolation & purification
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Viral Load
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Virus Integration / drug effects
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Virus Replication*