YopM puts caspase-1 on ice

Cell Host Microbe. 2012 Dec 13;12(6):737-8. doi: 10.1016/j.chom.2012.11.006.

Abstract

Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacterial Outer Membrane Proteins / metabolism*
  • Caspase 1 / metabolism*
  • Ice
  • Inflammasomes / antagonists & inhibitors*
  • Virulence Factors / metabolism*
  • Yersinia
  • Yersinia pestis / immunology*

Substances

  • Bacterial Outer Membrane Proteins
  • Ice
  • Inflammasomes
  • Virulence Factors
  • yopM protein, Yersinia
  • Caspase 1