Abstract
Although some studies have reported relationships between cytogenetic subgroups, molecular markers and age in acute myeloid leukemia (AML), conclusions based on data from a Chinese population are lacking. In the present study, we evaluated 640 patients with de novo AML. The patients were divided into 8 age groups, i.e. 0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69 and ≥70 years, and were then classified into cytogenetic groups based on normal, balanced and unbalanced karyotypes.
Publication types
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Clinical Trial
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Multicenter Study
MeSH terms
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Abnormal Karyotype*
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Adolescent
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Asian People
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Biomarkers, Tumor / metabolism*
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Child
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China / epidemiology
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Female
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Humans
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Leukemia, Myeloid, Acute* / epidemiology
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Leukemia, Myeloid, Acute* / metabolism
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Leukemia, Myeloid, Acute* / pathology
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Leukocyte Count
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Male
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Middle Aged
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Nuclear Proteins / metabolism*
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Nucleophosmin
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Proto-Oncogene Proteins c-kit / metabolism*
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fms-Like Tyrosine Kinase 3 / metabolism*
Substances
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Biomarkers, Tumor
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Nuclear Proteins
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Nucleophosmin
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FLT3 protein, human
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Proto-Oncogene Proteins c-kit
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fms-Like Tyrosine Kinase 3