Retooling spare parts: gene duplication and cognition

T Grant Belgard; Daniel H Geschwind

doi:10.1038/nn.3292

Retooling spare parts: gene duplication and cognition

Nat Neurosci. 2013 Jan;16(1):6-8. doi: 10.1038/nn.3292.

Authors

T Grant Belgard¹, Daniel H Geschwind

Affiliation

¹ Center for Autism Research and Treatment and the Program in Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA.

PMID: 23257927
PMCID: PMC4090687
DOI: 10.1038/nn.3292

Abstract

Two new studies experimentally demonstrate how ancient genomic duplications of synaptic genes provided the substrate for diversification that ultimately expanded vertebrate cognitive complexity.

Publication types

Comment

MeSH terms

Animals
Behavior, Animal / physiology*
Biological Evolution*
Cognition Disorders / genetics*
Cognition Disorders / pathology*
Cytoplasm / metabolism*
Evolution, Molecular*
Female
Humans
Male
Neuronal Plasticity / physiology*
Receptors, N-Methyl-D-Aspartate / metabolism*
Synapses / genetics*
Synapses / physiology*

Substances

NR2B NMDA receptor
Receptors, N-Methyl-D-Aspartate
N-methyl D-aspartate receptor subtype 2A

Grants and funding

R37 MH060233/MH/NIMH NIH HHS/United States