Abstract
Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, affecting 1-2% of the general population. BAV is frequently associated with significant aortic pathology (valve regurgitation, endocarditis, severe aortic stenosis, aortic aneurysm and dissection) accounting for considerable morbidity and mortality. Despite its clinical relevance, the pathogenesis of BAV disease and its complications remain largely unknown. The purpose of this paper is to discuss and summarize our current understanding of BAV in terms of epidemiology, genetics and clinics.
MeSH terms
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Aortic Aneurysm / diagnosis
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Aortic Aneurysm / genetics
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Aortic Coarctation / diagnosis
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Aortic Coarctation / genetics
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Aortic Dissection / diagnosis
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Aortic Dissection / genetics
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Aortic Valve / abnormalities
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Aortic Valve Stenosis / diagnosis
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Aortic Valve Stenosis / genetics
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Bicuspid Aortic Valve Disease
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Diagnosis, Differential
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Echocardiography
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Evidence-Based Medicine
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Heart Defects, Congenital / diagnosis*
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Heart Defects, Congenital / epidemiology
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Heart Defects, Congenital / genetics*
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Heart Valve Diseases / diagnosis*
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Heart Valve Diseases / epidemiology
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Heart Valve Diseases / genetics*
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Humans
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Italy / epidemiology
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Magnetic Resonance Angiography
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Magnetic Resonance Imaging, Cine
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Predictive Value of Tests
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Prevalence
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Sensitivity and Specificity