[Acute miliary tuberculosis or Isambert disease: a case report]

Arch Pediatr. 2013 Jan;20(1):41-3. doi: 10.1016/j.arcped.2012.10.010. Epub 2012 Dec 21.
[Article in French]

Abstract

Pharynx tuberculosis consists in a set of active lesions in granulomatous-type mucosa, resulting from Mycobacterium tuberculosis infection. In an endemic context, this diagnosis should be raised in cases of head and neck disease. A recent observation of a case of acute miliary tuberculosis gave us the opportunity to conduct a literature review of this disorder. This 9-year-old girl presented with dysphagia associated with pharyngeal discomfort, snoring, and hoarseness lasting for 8 months. This pharyngeal syndrome occurred in the context of an impaired general condition. Clinical examination found a diffuse mucosal granulation aspect in the oropharynx. The workup showed an inflammatory syndrome with a strong positive intradermal tuberculin reaction. The biopsy found an aspect of giant cell granuloma with caseous necrosis. The course was favorable on antituberculous chemotherapy. Tuberculosis is a chronic bacterial infection caused by a bacterium belonging to the M. tuberculosis complex. Pharyngeal tuberculosis remains a rare disease, but several epidemiological parameters show an upsurge of this disease, prompting us to report this observation.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Disease
  • Antitubercular Agents / therapeutic use
  • Biopsy
  • Child
  • Deglutition Disorders / microbiology
  • Diagnosis, Differential
  • Female
  • Hoarseness / microbiology
  • Humans
  • Pharyngeal Diseases / diagnosis*
  • Pharyngeal Diseases / drug therapy
  • Pharyngeal Diseases / microbiology
  • Rare Diseases
  • Snoring / microbiology
  • Treatment Outcome
  • Tuberculin Test
  • Tuberculosis, Miliary / complications
  • Tuberculosis, Miliary / diagnosis*
  • Tuberculosis, Miliary / drug therapy

Substances

  • Antitubercular Agents