Chronic progressive external ophthalmoplegia coexistent with motor neuron disease in a patient with a novel large-scale mitochondrial DNA deletion

Clin Neurol Neurosurg. 2013 Aug;115(8):1490-2. doi: 10.1016/j.clineuro.2012.11.011. Epub 2012 Dec 23.

Authors

Danhua Zhao¹, Zhaoxia Wang, Daojun Hong, Wei Zhang, Yun Yuan

Affiliation

¹ Department of Neurology, Peking University First Hospital, Beijing 100034, PR China.

PMID: 23266267
DOI: 10.1016/j.clineuro.2012.11.011

No abstract available

Keywords: Chronic progressive external ophthalmoplegia; Large-scale deletion; Mitochondrial DNA; Motor neuron disease.

Publication types

Case Reports

MeSH terms

Aged
Atrophy
Blotting, Southern
DNA, Mitochondrial / genetics*
Fasciculation / etiology
Fasciculation / physiopathology
Gene Deletion*
Humans
Male
Motor Neuron Disease / complications*
Muscle Fibers, Skeletal / pathology
Muscle Weakness / etiology
Muscle, Skeletal / chemistry
Ophthalmoplegia, Chronic Progressive External / etiology*
Polymerase Chain Reaction

Substances

DNA, Mitochondrial