A 73-year-old man was referred to our hospital because of ileus. Enteroscopy revealed severe stenosis in the jejunum. He was diagnosed with small intestinal cancer. Partial resection of the jejunum, partial resection of the transverse colon, and lymphadenectomy were performed. A postoperative pathological examination showed skip metastasis in the jejunum (TNM: Stage IV). Six months later, lung and liver metastases were evident from computed tomography( CT). Nine courses of FOLFOX6 administered once every 2 weeks achieved a partial response. When 9 courses of chemotherapy had been completed, CT showed progressive disease. Subsequently, he has been administered with FOLFIRI in our outpatient clinic.