Abstract
Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Andrographis / chemistry*
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Carbon-13 Magnetic Resonance Spectroscopy
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Cell Line
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Cell Survival / drug effects
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Chromatography, Liquid
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Flavanones / pharmacology
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Flavones / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / pathology
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Mice
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Nitric Oxide / biosynthesis
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Proton Magnetic Resonance Spectroscopy
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Tandem Mass Spectrometry
Substances
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Anti-Inflammatory Agents
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Flavanones
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Flavones
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Lipopolysaccharides
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Nitric Oxide