Abstract
The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Geologic Sediments / chemistry*
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Histone-Lysine N-Methyltransferase / antagonists & inhibitors*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology*
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Streptomyces / chemistry*
Substances
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Polyketides
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nahuoic acid A
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Histone-Lysine N-Methyltransferase