Cystic adventital disease is a very rare lesion of peripheral arteries. The cysts usually occur in the popliteal arteries, they contain gelatinous substance and by eccentric compression of the lumen of the artery may cause calf claudication. We report a case of decompression of the popliteal artery by percutaneous ultrasound guided adventitial cyst aspiration in an 80-year-old patient complaining of intermittent claudication. The procedure resulted in normal flow in the popliteal artery and resolution of symptoms. Such procedure is efficacious, safe and can be performed on an outpatient basis.