Abstract
The present review focuses on the synthesis and biological evaluation of polycyclic 4(3H)-quinazolinones containing fused aromatic or heteroaromatic rings. The first part of the review is related to compounds with ring fused to the pyrimidine part of the quinazoline core. Most of the quinazolinone alkaloids belong to this class of molecules. The second part presents molecules bearing extra ring(s) fused to the benzo moiety of the quinazolinone skeleton. Their structural diversity opens new fields in the search of active molecules.
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Bacteria / drug effects
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Bacterial Infections / drug therapy
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Chemistry Techniques, Synthetic / methods
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Fungi / drug effects
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Humans
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Mycoses / drug therapy
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Neoplasms / drug therapy
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Quinazolinones / chemical synthesis
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Quinazolinones / chemistry*
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Quinazolinones / pharmacology*
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Quinazolinones