Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

Nutrition. 2013 Mar;29(3):537-41. doi: 10.1016/j.nut.2012.09.014. Epub 2013 Jan 1.

Abstract

Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12.

Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls).

Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels.

Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autistic Disorder / complications*
  • Case-Control Studies
  • Child, Preschool
  • Diet*
  • Female
  • Folic Acid / administration & dosage
  • Folic Acid / blood
  • Folic Acid Deficiency / complications*
  • Folic Acid Deficiency / epidemiology
  • Homocysteine / blood
  • Humans
  • Male
  • Nutrition Assessment
  • Nutritional Status
  • Odds Ratio
  • Oman / epidemiology
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / blood
  • Vitamin B 12 Deficiency / complications*
  • Vitamin B 12 Deficiency / epidemiology

Substances

  • Homocysteine
  • Folic Acid
  • Vitamin B 12