Abstract
A steroidal glycolipid that enhances the nonspecific cellular response to opportunistic infection in an immunocompromised host has been discovered. A dose dependent response with 6-(5-cholesten-3 beta-yloxy)hexyl 1-thio-beta-D-mannopyranoside, L-644,257, was observed against several infective agents including bacterial, fungal, and viral pathogens in cyclophosphamide-treated mice. A mechanism for this protective action is proposed.
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / pharmacology*
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Administration, Oral
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Animals
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Candidiasis / immunology
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Cholesterol / administration & dosage
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Cholesterol / analogs & derivatives*
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Cholesterol / pharmacology
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Female
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Immunity, Innate / drug effects*
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Injections, Intramuscular
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Injections, Intraperitoneal
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Injections, Subcutaneous
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Mice
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Pseudomonas Infections / immunology
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Staphylococcal Infections / immunology
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Time Factors
Substances
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Adjuvants, Immunologic
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L 644257
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Cholesterol