Photoresponsive cross-linked polymeric particles for phototriggered burst release

Photochem Photobiol. 2013 May-Jun;89(3):552-9. doi: 10.1111/php.12038. Epub 2013 Jan 29.

Abstract

We synthesized a series of cross-linked photoresponsive polymeric particles with photolabile monomers and cross-linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Cell Line
  • Cell Survival / drug effects
  • Emulsions
  • Ethanol / analogs & derivatives
  • Ethanol / chemistry
  • Fluoresceins
  • Fluorescent Dyes
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Methacrylates / chemical synthesis*
  • Methacrylates / pharmacology
  • Mice
  • Microscopy, Electron, Scanning
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Nitrobenzenes / chemistry
  • Oxazines
  • Particle Size
  • Polymerization
  • Spectrometry, Fluorescence
  • Ultraviolet Rays

Substances

  • Emulsions
  • Fluoresceins
  • Fluorescent Dyes
  • Methacrylates
  • Nitrobenzenes
  • Oxazines
  • 1-(2-nitrophenyl)ethanol
  • Ethanol
  • nile red
  • diacetylfluorescein