Abstract
A total of 146 group B streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. A high prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin, (53.4%), and tetracycline (81.5%). The levofloxacin and clindamycin resistances among the 4 serotypes differed significantly. Eighty percent of fluoroquinolone-resistant isolates belonged to the sequence type 19 (ST19)/serotype III clone, with GyrA-ParC-ParE triple substitutions. This clone carried the erm(B), mef(E), and tet(M) genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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China / epidemiology
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Clindamycin / pharmacology
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Clindamycin / therapeutic use*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial / drug effects
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Erythromycin / pharmacology
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Erythromycin / therapeutic use*
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Genes, Bacterial*
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Humans
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Levofloxacin*
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Middle Aged
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Mutation
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Ofloxacin / pharmacology
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Ofloxacin / therapeutic use*
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Prevalence
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Serotyping
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Streptococcal Infections / drug therapy*
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Streptococcal Infections / epidemiology
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Streptococcal Infections / microbiology
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / genetics
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Streptococcus agalactiae / isolation & purification
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Tetracycline / pharmacology
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Tetracycline / therapeutic use*
Substances
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Anti-Bacterial Agents
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Clindamycin
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Erythromycin
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Levofloxacin
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Ofloxacin
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DNA Topoisomerase IV
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DNA Gyrase
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Tetracycline