Abstract
In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus. Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Brain Diseases / chemically induced*
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Brain Diseases / diagnosis
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Child
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects*
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Female
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Humans
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Injections, Spinal
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Medication Errors*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy