Abstract
Three weeks after a single intravitreal injection of ethylcholine aziridinium ion (AF64A), there was a significant depletion of retinal acetylcholine (ACh) content. The depletion was accompanied by an increase of [3H]quinuclidinyl benzilate binding sites and a greater than control conversion of myo-[3H]inositol to inositol monophosphate following incubation with ACh. These changes are consistent with receptor supersensitivity due to AF64A-induced denervation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / metabolism*
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Animals
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Aziridines / pharmacology*
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Choline / analogs & derivatives*
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Choline / pharmacology
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Injections
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Inositol Phosphates / metabolism
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Male
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Quinuclidinyl Benzilate / metabolism
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Rats
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Rats, Inbred Strains
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Receptors, Muscarinic / drug effects
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Receptors, Muscarinic / metabolism*
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Retina / drug effects
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Retina / metabolism*
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Vitreous Body
Substances
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Aziridines
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Inositol Phosphates
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Receptors, Muscarinic
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Quinuclidinyl Benzilate
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ethylcholine aziridinium
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Choline
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Acetylcholine