A new phenylpropanoid glycoside from the fruits of Illicium simonsii

Chin J Nat Med. 2012 Jan;10(1):20-3. doi: 10.1016/S1875-5364(12)60004-1.

Abstract

Aim: To study the constituents and bioactivity of Illicium simonsii.

Methods: The extracts of the fruits of Illicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method.

Results: A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2-O-β-D-glucopyranoside (1), together with seven characteristic sesquiterpene lactones, oligandrumin B (2), oligandrumin D (3), anisatin (4), veranisatin D (5), pseudomajucin (6), 1α-hydroxy-3-deoxy-pseudoanisatin (7), 8α-hydroxy-10-deoxycyclomerrillianolide (8) were isolated.

Conclusion: Compound 1 is new. Compounds 1, 2, 3, 5-8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Fruit / chemistry*
  • Humans
  • Illicium / chemistry*
  • Lactones / isolation & purification
  • Monosaccharides / isolation & purification*
  • Plant Extracts / chemistry*
  • Sesquiterpenes / isolation & purification

Substances

  • 2,4-dihydroxy-allylbenzene-2-O-beta-D-glucopyranoside
  • Lactones
  • Monosaccharides
  • Plant Extracts
  • Sesquiterpenes