Molecular epidemiological surveillance of multidrug-resistant Pseudomonas aeruginosa isolates in a pediatric population of patients with cystic fibrosis and determination of risk factors for infection with the Houston-1 strain

J Clin Microbiol. 2013 Apr;51(4):1237-40. doi: 10.1128/JCM.02157-12. Epub 2013 Jan 9.

Abstract

Multiyear molecular epidemiological surveillance of multidrug-resistant Pseudomonas aeruginosa (MRPA) in a pediatric cystic fibrosis care center identified an endemic MRPA strain (Houston-1). Recent hospitalization was found to be a statistically significant risk factor for acquisition of the endemic strain. Multiple infection control improvements led to the reduced incidence of the Houston-1 strain in the CF population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Cystic Fibrosis / complications*
  • Drug Resistance, Multiple, Bacterial*
  • Genotype
  • Hospitals, Pediatric
  • Humans
  • Incidence
  • Infection Control / methods
  • Molecular Epidemiology
  • Molecular Typing
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / classification
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / genetics*
  • Pseudomonas aeruginosa / isolation & purification
  • Risk Factors