Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia

Fitoterapia. 2013 Mar:85:64-8. doi: 10.1016/j.fitote.2012.12.030. Epub 2013 Jan 10.

Abstract

Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13μg/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification*
  • Meliaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*

Substances

  • Anti-Bacterial Agents
  • Triterpenes
  • aphagrandinoid A
  • cycloartane