Abstract
Moving objects can cover large distances while they are processed by the eye, usually resulting in a spatially lagged retinal response. We identified a network of electrically coupled motion-coding neurons in mouse retina that act collectively to register the leading edges of moving objects at a nearly constant spatial location, regardless of their velocity. These results reveal a previously unknown neurophysiological substrate for lag normalization in the visual system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology*
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Animals
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Biophysics
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Electric Stimulation
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Gap Junctions / drug effects
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Gap Junctions / physiology*
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Glycyrrhetinic Acid / pharmacology
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Green Fluorescent Proteins / genetics
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Green Fluorescent Proteins / metabolism
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Homeodomain Proteins / genetics
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Models, Neurological
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Motion Perception / physiology*
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Neurons / drug effects
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Neurons / physiology*
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Patch-Clamp Techniques
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Photic Stimulation
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Reaction Time / physiology
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Retina / cytology
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Space Perception / physiology
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Transcription Factors / genetics
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Visual Pathways / drug effects
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Visual Pathways / physiology*
Substances
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Homeodomain Proteins
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Transcription Factors
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enhanced green fluorescent protein
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Hb9 protein, mouse
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Green Fluorescent Proteins
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Glycyrrhetinic Acid