Glucose sensing via aggregation and the use of "knock-out" binding to improve selectivity

J Am Chem Soc. 2013 Feb 6;135(5):1700-3. doi: 10.1021/ja311442x. Epub 2013 Jan 29.

Abstract

Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by "knock-out" binding of fructose by phenylboronic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Boronic Acids / chemistry*
  • Fluorescent Dyes / chemistry*
  • Fructose / chemistry*
  • Glucose / analysis*
  • Hydrophobic and Hydrophilic Interactions
  • Models, Molecular
  • Molecular Structure
  • Pyrenes / chemistry*
  • Spectrometry, Fluorescence
  • Substrate Specificity

Substances

  • Boronic Acids
  • Fluorescent Dyes
  • Pyrenes
  • Fructose
  • pyrene
  • Glucose