Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

Junseok Lee; Juhee Park; Kaushik Singha; Won Jong Kim

doi:10.1039/c2cc38510d

Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

Chem Commun (Camb). 2013 Feb 21;49(15):1545-7. doi: 10.1039/c2cc38510d.

Authors

Junseok Lee¹, Juhee Park, Kaushik Singha, Won Jong Kim

Affiliation

¹ Department of Chemistry, Center for Self-assembly and Complexity, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang, 790-784, Republic of Korea.

PMID: 23325385
DOI: 10.1039/c2cc38510d

Abstract

A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with long-wavelength light.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / chemistry*
Indoles / chemistry
Isoindoles
Nanoparticles / chemistry*
Organometallic Compounds / chemistry
Photosensitizing Agents / chemistry*
Porosity
Silicon Dioxide / chemistry*
Singlet Oxygen / chemistry*
Zinc Compounds

Substances

Drug Carriers
Indoles
Isoindoles
Organometallic Compounds
Photosensitizing Agents
Zinc Compounds
Zn(II)-phthalocyanine
Singlet Oxygen
Silicon Dioxide