Abstract
Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC(50) value of 43.0 μM when evaluated using a zebrafish model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / isolation & purification*
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Angiogenesis Inhibitors / pharmacology
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Animals
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Disease Models, Animal
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Euphorbia / chemistry*
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Zebrafish
Substances
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Angiogenesis Inhibitors
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Diterpenes
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Drugs, Chinese Herbal
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sikkimenoid B