A one-year follow-up of antibody response in cattle and sheep after vaccination with serotype 8- and serotype 1-inactivated BT vaccines

Transbound Emerg Dis. 2014 Oct;61(5):473-6. doi: 10.1111/tbed.12048. Epub 2013 Jan 19.

Abstract

Sixteen sheep and 18 cattle were followed up during 1 year to estimate the duration of immunity induced by inactivated bluetongue virus serotype 8 (BTV-8) vaccines (sheep and cattle) and a bluetongue virus serotype 1 (BTV-1) vaccine (cattle) under field conditions using cELISA and seroneutralization test (SNT). Four sheep never seroconverted. Those that seroconverted were all seronegative by BTV-8 SNT at the date of last sampling [378 days post-vaccination (dpv)]. Eight sheep were still positive by competitive ELISA (cELISA) 378 dpv. All the cattle seroconverted. At the end of the study, eight and 11 cattle were still positive by BTV-8 SNT and cELISA, respectively (335 dpv); and nine were still positive by BTV-1 SNT (301 dpv).

Keywords: BTV-1; BTV-8; SNT; bluetongue; cELISA; humoral response; inactivated vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology
  • Bluetongue / prevention & control*
  • Bluetongue virus / immunology*
  • Cattle
  • Cattle Diseases / prevention & control*
  • Enzyme-Linked Immunosorbent Assay / veterinary
  • Serotyping
  • Sheep
  • Vaccination / veterinary
  • Vaccines, Inactivated
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Viral
  • Vaccines, Inactivated
  • Viral Vaccines