Bone metastases from prostate cancer: 18F-fluoride PET/CT in a patient with discordant bone scintigraphy and 11C-choline PET/CT

Clin Nucl Med. 2013 Feb;38(2):120-4. doi: 10.1097/RLU.0b013e31827a20d3.

Abstract

Bone scintigraphy has been used extensively in prostate cancer patients to detect bone involvement. (11)C-choline PET/CT is indicated when a biochemical recurrence is suspected, as this procedure is able to detect local recurrence, lymph-node infiltration, and metastases.In cases where the results of these 2 procedures do not coincide, MRI is then usually performed. (18)F-fluoride may become an alternative to MRI for bone imaging.In our patient series, all bone lesions with (11)C-choline uptake were metastases. (18)F-Fluoride did not increase specificity of (11)C-choline but increased sensitivity of bone scintigraphy. CT helped in the interpretation of osteoarthritis and trauma lesions.

Publication types

  • Case Reports

MeSH terms

  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / pathology
  • Bone Neoplasms / physiopathology
  • Bone Neoplasms / secondary*
  • Carbon Radioisotopes
  • Choline*
  • Fluorides*
  • Fluorine Radioisotopes*
  • Humans
  • Male
  • Multimodal Imaging*
  • Positron-Emission Tomography*
  • Prostatic Neoplasms / pathology*
  • Tomography, X-Ray Computed*

Substances

  • Carbon Radioisotopes
  • Fluorine Radioisotopes
  • Choline
  • Fluorides