Abstract
We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acoustics*
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Adaptive Immunity / drug effects
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Animals
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Biomimetic Materials / chemistry*
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Biomimetic Materials / pharmacology
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Cell Line, Tumor
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Contrast Media / chemistry*
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Contrast Media / pharmacology
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Cytokines / metabolism
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Humans
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Indocyanine Green / chemistry*
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Injections, Intravenous
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Mice
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Microscopy, Confocal
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Nanostructures / chemistry*
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Temperature
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Viruses / chemistry*
Substances
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Contrast Media
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Cytokines
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Indocyanine Green