Small gap sleeve bridging can improve the accuracy of peripheral nerve selective regeneration

Artif Cells Nanomed Biotechnol. 2013 Dec;41(6):402-7. doi: 10.3109/21691401.2012.762007. Epub 2013 Jan 22.

Abstract

The pure motor peripheral nerves animal model, obtained by ablating the dorsal root ganglions (DRGs), was used to investigate the accuracy of peripheral nerve selective regeneration using small gap sleeve bridging compared to epineurium neurorrhaphy. The results showed that the number of improperly regenerated motor axons in the distal stump and the misrouting ratio were significantly lower when the nerve transection was treated by small gap sleeve bridging. This suggests that more accurate reinnervation may be achieved by small gap sleeve bridging than by traditional epineurium neurorrhaphy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / metabolism
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / physiology
  • Male
  • Nerve Regeneration*
  • Peripheral Nerves / cytology
  • Peripheral Nerves / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Engineering / methods*