Abstract
Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein response (UPR) and autophagy. In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of the UPR transcription factor XBP1 in the modulation of autophagy through the control of FoxO1 turnover.
MeSH terms
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DNA-Binding Proteins / genetics*
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Forkhead Box Protein O1
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Forkhead Transcription Factors / genetics*
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Gene Expression Regulation, Neoplastic*
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Glutamine / deficiency*
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Humans
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Regulatory Factor X Transcription Factors
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Transcription Factors / genetics*
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X-Box Binding Protein 1
Substances
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DNA-Binding Proteins
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FOXO1 protein, human
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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Regulatory Factor X Transcription Factors
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Transcription Factors
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X-Box Binding Protein 1
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XBP1 protein, human
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Glutamine